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Potential functions of esophageal cancer-related gene-4 in the cardiovascular system
Rui Zhou, Yuanshu Liu, Wenjun Huang, Xitong Dang
《医学前沿(英文)》 2019年 第13卷 第6期 页码 639-645 doi: 10.1007/s11684-019-0701-0
关键词: tumor suppressor gene esophageal cancer-related gene-4 cardiovascular disease hypoxia
ECRG4: a new potential target in precision medicine
Xin Qin, Ping Zhang
《医学前沿(英文)》 2019年 第13卷 第5期 页码 540-546 doi: 10.1007/s11684-018-0637-9
关键词: ECRG4 tumor suppressor gene sentinel molecule precision medicine cell senescence epithelium homeostasis
Gene expression disparity in giant cell tumor of bone
Xiaohua PAN, Shuhua YANG, Deming XIAO, Yong DAI, Lili REN
《医学前沿(英文)》 2009年 第3卷 第1期 页码 49-56 doi: 10.1007/s11684-009-0012-y
Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells
null
《医学前沿(英文)》 2018年 第12卷 第4期 页码 374-386 doi: 10.1007/s11684-018-0652-x
A family of transcription factors known as Id proteins, or inhibitor of DNA binding and differentiation, is capable of regulating cell proliferation, survival and differentiation, and is often upregulated in multiple types of tumors. Due to their ability to promote self-renewal, Id proteins have been considered as oncogenes, and potential therapeutic targets in cancer models. On the contrary, certain Id proteins are reported to act as tumor suppressors in the development of Burkitt’s lymphoma in humans, and hepatosplenic and innate-like T cell lymphomas in mice. The contexts and mechanisms by which Id proteins can serve in such contradictory roles to determine tumor outcomes are still not well understood. In this review, we explore the roles of Id proteins in lymphocyte development and tumorigenesis, particularly with respect to inhibition of their canonical DNA binding partners known as E proteins. Transcriptional regulation by E proteins, and their antagonism by Id proteins, act as gatekeepers to ensure appropriate lymphocyte development at key checkpoints. We re-examine the derailment of these regulatory mechanisms in lymphocytes that facilitate tumor development. These mechanistic insights can allow better appreciation of the context-dependent roles of Id proteins in cancers and improve considerations for therapy.
关键词: Id proteins lymphoma leukemia T cells B cells tumor suppressor oncogene
662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)
QU Yanchun, YANG Ze, SUN Liang, JI Linong
《医学前沿(英文)》 2008年 第2卷 第3期 页码 283-285 doi: 10.1007/s11684-008-0053-7
关键词: D-HPLC mutation development autoimmune PCR-RFLP candidate
Antitumor immunity of human SART3 gene vaccine against mouse tumor
HE Yu, YANG Shuhua, LIU Yong, LI Tao
《医学前沿(英文)》 2008年 第2卷 第1期 页码 51-57 doi: 10.1007/s11684-008-0010-5
关键词: antitumor therapy occurrence implantation DNA vaccine SART3 DNA
Fen LAN, Shengdao XIONG, Weining XIONG, Guopeng XU, Xiaoxia LU
《医学前沿(英文)》 2009年 第3卷 第1期 页码 41-44 doi: 10.1007/s11684-009-0009-6
关键词: Syk kinase carcinoma non-small-cell lung tumor suppressor protein p53
A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes
《医学前沿(英文)》 2023年 第17卷 第3期 页码 458-475 doi: 10.1007/s11684-022-0968-4
关键词: LU domain-containing protein family novel human gene LY6A pituitary tumor biomarker nonsynonymous SNP GPI-anchored protein
Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cell
Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 106-111 doi: 10.1007/s11684-010-0004-y
关键词: hepatitis B virus X gene glomerular mesangial cell line extracellular regulated protein kinases tumor necrosis factor-α
Xiu-Liang TAO MM, Sheng-Hao TU MD, Ri-Bo XIONG MM, Yong-Hong HU BM,
《医学前沿(英文)》 2010年 第4卷 第2期 页码 220-224 doi: 10.1007/s11684-010-0025-6
关键词: arthritis rheumatoid molonuclear cells tumor necrosis factor gene polymorphisms triptolid
Molecular characterization of two suppressor of cytokine signaling 1 genes (
Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG
《农业科学与工程前沿(英文)》 2015年 第2卷 第1期 页码 73-83 doi: 10.15302/J-FASE-2015044
李永洁,杨俊涛,杜建
《中国工程科学》 2018年 第20卷 第6期 页码 64-68 doi: 10.15302/J-SSCAE-2018.06.010
随着医学与现代信息技术、材料科技等技术的深度交叉融合,极大地促进了医学科技的发展,疾病诊断和治疗模式发生革命性的变化。本文主要从医学领域的肿瘤免疫治疗、基因编辑技术、医学人工智能、合成生物学技术和干细胞与转化医学五个技术方向,分析评价其发展态势;结合文献、智库报告和专家观点,对医学科技发展方向进行初探,提出重视医学基础研究投入、优化医学科技战略顶层设计、完善政策及监管体系等政策建议。
Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113
Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 357-362 doi: 10.1007/s11684-009-0046-1
关键词: carcinoma squamous cell pituitary tumor transforming gene (PTTG) protein basic fibroblast growth factor
Heterogeneity of the tumor immune microenvironment and clinical interventions
《医学前沿(英文)》 2023年 第17卷 第4期 页码 617-648 doi: 10.1007/s11684-023-1015-9
Recent advances in myeloid-derived suppressor cell biology
Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani, Ammar Daoud
《医学前沿(英文)》 2021年 第15卷 第2期 页码 232-251 doi: 10.1007/s11684-020-0797-2
关键词: non-human primates (rhesus macaques) myeloid-derived pro-inflammatory cells (MDPCs) autoimmune disorders alloimmune responses pregnancy mature MDSCs multiple sclerosis Yin-Yang law of MDSCs
标题 作者 时间 类型 操作
Potential functions of esophageal cancer-related gene-4 in the cardiovascular system
Rui Zhou, Yuanshu Liu, Wenjun Huang, Xitong Dang
期刊论文
Gene expression disparity in giant cell tumor of bone
Xiaohua PAN, Shuhua YANG, Deming XIAO, Yong DAI, Lili REN
期刊论文
662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)
QU Yanchun, YANG Ze, SUN Liang, JI Linong
期刊论文
Antitumor immunity of human SART3 gene vaccine against mouse tumor
HE Yu, YANG Shuhua, LIU Yong, LI Tao
期刊论文
Expression of Syk in non-small cell lung cancer and its relationship with clinicopathological parameters
Fen LAN, Shengdao XIONG, Weining XIONG, Guopeng XU, Xiaoxia LU
期刊论文
A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes
期刊论文
Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cell
Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,
期刊论文
TNF-alpha secretion from peripheral blood monocular cells by triptolid is associated with TNF-alpha-308 gene
Xiu-Liang TAO MM, Sheng-Hao TU MD, Ri-Bo XIONG MM, Yong-Hong HU BM,
期刊论文
Molecular characterization of two suppressor of cytokine signaling 1 genes (
Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG
期刊论文
Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113
Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,
期刊论文